The Lille University Hospital is a participating center in the CARAMBA clinical study and an essential recruitment component and treatment center in this clinical trial. The immunology and hematology labs are able to perform all CAR-T cell enumeration and post-infusion toxicity monitoring as well as MRD by flow cytometry and NG. The CHU-Lille will also take responsibility for obtaining regulatory approval for the trial in France. The clinical karamba 60 trial unit is led by Dr Petillon with trained trial nurses and data managers , experienced in both clinical trials including early phase and bone marrow transplant. Additionally, it is part of a translational research program in multiple myeloma within the URM S1128 INSERM unit and has access to a large molecular biology sequencing platform. Involved in clinical trial preparation, monitoring and next-generation CAR development.
Allogeneic Stem Cell Transplantation especially in patients with Myelodysplastic Syndrome and expert in CAR-T approaches. In vitro and in vivo genome editing strategies for the development of advanced therapies. Dr. Paula Rodríguez-Otero leads the clinical trials and immunotherapy program under the direction of Prof. Jesus San Miguel. i modded it to use amarok, karamba 60 removed the mail, got a better font, show uptime, kde version, removed a couple harddrives and added vol up/down for amarok. very nice theme, however, the cpu use is much too high because of the default intervalls. 1.3 includes also the 1.1 theme and i fixed a small problem with the kmailpart. i have started a secound theme, because the first is too high.
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The Universitätsklinikum Würzburg is the coordinating institution in CARAMBA and responsible for the successful conduct of the phase I/IIa clinical trial with SLAMF7 CAR-T cells, being an essential recruitment and treatment center. The UKW team will also lead the effort for obtaining German regulatory approval for the trial and project http://automaten-welt.de/spielautomaten/ management. I’ve seen so many and so good-looking bars for karamba that I decided to do one for myself. Note that you’ll need to edit the theme to get the apps to your own local paths. So just rpm -e the old rpm, or delete the old karamba binary if you compiled it yourself. Or configure the new one so that it installs over the old one.
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The research group Transposition and Genome Engineering within this division is concentrating on the development of transposon-based vector systems for regenerative medicine and gene therapy. in histocompatibility and cellular immunology of hematopoetic stem cell transplantation.

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• Regarding myeloma, there are three full-time consultants dedicated to the care of myeloma patients.
• The Lille University Hospital (CHU-Lille) is a large and experienced clinical and research facility that provides a strong infrastructure relevant for the proposed project, including one of the largest clinical myeloma programs in Europe.
• A large bone marrow transplantation unit performs more than 100 allogeneic transplants per year.
• There are three full time consultants dedicated to the management of these patients.
• Further, T-CURX shall lead the development to market authorization and commercial translation of the SLAMF7 CAR-T cell product after completion of the Phase I/IIa clinical trial in CARAMBA.
• The department has 58 in-patients beds and 30 day-care beds with additional out-patients facilities (100 patients/day).

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The primary purpose of these programmes is to develop a strong community of European myeloma advocates. Several years of experience in immunology, molecular biology and cellular biology. Preclinical research on transposon biology and development of a next-generation hyperactive Sleeping Beauty transposase. Preclinical research on transposon based gene delivery systems with a primary focus on advancing additional safety features in form of modifying integration profiles and developing novel suicide gene switches.
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